Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA.

@article{Lam2006HumanCC,
  title={Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA.},
  author={Ai Leen Lam and Christopher D. Boivin and Caitlin F Bonney and M Katharine Rudd and Beth A Sullivan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 11},
  pages={4186-91}
}
Human centromeres are specialized chromatin domains containing the centromeric histone H3 variant CENP-A. CENP-A nucleosomes are interspersed with nucleosomes containing histone H3 dimethylated at lysine 4, distinguishing centromeric chromatin (CEN chromatin) from flanking heterochromatin that is defined by H3 lysine 9 methylation. To understand the relationship between chromatin organization and the genomic structure of human centromeres, we compared molecular profiles of three endogenous… CONTINUE READING