Human cell mutagenicity of mono- and dinitropyrenes in metabolically competent MCL-5 cells.


Nitropyrenes are ubiquitous environmental pollutants that may pose a human health hazard because some are highly potent mutagens and carcinogens. The mutagenicity (trifluorothymidine resistance at the thymidine kinase locus) of 1-, 2-, and 4-nitropyrene (1-, 2-, and 4-NP), 1,3-, 1,6-, and 1,8-dinitropyrene (1,3-, 1,6-, and 1,8-DNP), and pyrene was assessed… (More)


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