Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.

@article{Dijk2007HumanCG,
  title={Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.},
  author={Erwin L van Dijk and Geurt W Schilders and Ger J. M. Pruijn},
  journal={RNA},
  year={2007},
  volume={13 7},
  pages={1027-35}
}
The human exosome is a 3'-5' exoribonuclease complex that functions both in the nucleus and in the cytoplasm to either degrade or process RNA. Little is known yet about potential differences among core exosome complexes in these different cellular compartments and the roles of the individual subunits in maintaining a stable and functional complex. Glycerol gradient sedimentation analyses indicated that a significant subset of nuclear exosomes is present in much larger complexes (60-80S) than… CONTINUE READING