Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59.

@article{Merwe1994HumanCM,
  title={Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59.},
  author={Philip Anton van der Merwe and A. Neil Barclay and Don W. Mason and Elizabeth A. Davies and Bradley Morgan and Masahide Tone and A K Krishnam and C J Ianelli and Simon J Davis},
  journal={Biochemistry},
  year={1994},
  volume={33 33},
  pages={10149-60}
}
CD2 is a T lymphocyte cell-adhesion molecule (CAM) belonging to the immunoglobulin superfamily (IgSF) which mediates transient adhesion of T cells to antigen-presenting cells and target cells. Reported ligands for human CD2 include the structurally-related IgSF CAMs CD58 (LFA-3) and CD48 as well as, more controversially, the unrelated cell-surface glycoprotein CD59. Using surface plasmon resonance technology, which avoids several pitfalls of conventional binding assays, we recently reported… CONTINUE READING

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