Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.

@article{Lenari1988HumanCB,
  title={Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.},
  author={Brigita Lenar{\vc}i{\vc} and Dusica Gabrijelcic and Branimir Rozman and Marina Drobnic-Kosorok and Vito Turk},
  journal={Biological chemistry Hoppe-Seyler},
  year={1988},
  volume={369 Suppl},
  pages={
          257-61
        }
}
Synovial fluid of patients with different inflammatory and metabolic joint diseases contains low-molecular CPIs (stefins and cystatins) and high-molecular CPIs (kininogens). An additional inhibitory fragment with a molecular mass of about 20 kDa, which is a part of the kininogen molecule, has been detected. Cathepsin B and cystatin C were determined by ELISA test in 47 patients with rheumatoid arthritis, seronegative spondylarthritis, osteoarthritis, undifferentiated arthritis and gout. A… CONTINUE READING

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