Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3

  title={Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3},
  author={Adrian F. Gombart and Niels Borregaard and H. Phillip Koeffler},
  journal={The FASEB Journal},
  pages={1067 - 1077}
The innate immune system of mammals provides a rapid response to repel assaults from numerous infectious agents including bacteria, viruses, fungi, and parasites. A major component of this system is a diverse combination of cationic antimicrobial peptides that include the α‐ and β‐defensins and cathelicidins. In this study, we show that 1,25‐dihydroxyvitamin D3 and three of its analogs induced expression of the human cathelicidin antimicrobial peptide (CAMP) gene. This induction was observed in… 

A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression

Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

  • John H. White
  • Biology
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2010

PU.1 and epigenetic signals modulate 1,25‐dihydroxyvitamin D3 and C/EBPα regulation of the human cathelicidin antimicrobial peptide gene in lung epithelial cells

These findings identify key mediators involved in the regulation of the CAMP gene in lung epithelial cells and suggest new approaches for therapeutic manipulation of gene expression to increase the antibacterial capability of the airway.

The Essential Role of Vitamin D in the Biosynthesis of Endogenous Antimicrobial Peptides May Explain Why Deficiency Increases Mortality Risk in COVID-19 Infections

Evidence suggesting that higher daily intakes of vitamin D3 than the currently recommended 600 (15 mcg) IU/day may be necessary to sustain AMP production in the face of an overwhelming infection is reviewed, particularly in non-Hispanic blacks, a high risk population suffering the worst outcomes from COVID-19.

Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids.

These findings demonstrate for the first time that stilbenoid compounds may have the potential to boost the innate immune response by increasing CAMP gene expression, particularly in combination with 1α,25(OH)2 D3.

C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells

It is demonstrated that C/EBP alpha (C/E BPα) is a potent enhancer of human cathelicidin antimicrobial peptide (CAMP) gene transcription in human lung epithelial cells and that C-EBPα functionally cooperates with VDR in the regulation of CAMP transcription.

Activity of Antimicrobial Peptide; Cathelicidin, on Bacterial Infection

Cathelicidin is found to have upregulation when there is bacterial infection, and the most effective expression inducer of CAMP gene is 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3), which is the active form of vitamin D.

Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity

The evidence for 1,25D-induced antimicrobial activity in vitro and in vivo in humans is surveyed and the current understanding of the potential mechanisms by which CAMP and HBD2/DEFB4 contribute to antiviral immunity is presented.



The Human Cationic Antimicrobial Protein (hCAP18), a Peptide Antibiotic, Is Widely Expressed in Human Squamous Epithelia and Colocalizes with Interleukin-6

The finding that h CAP18 is widely produced in squamous epithelia suggests a role for this peptide in epithelial antimicrobial defense, and colocalization with interleukin-6 indicates a potential local mechanism for the upregulation of hCAP18 at the epithelial surfaces.

Cutting Edge: Mast Cell Antimicrobial Activity Is Mediated by Expression of Cathelicidin Antimicrobial Peptide 1

Different antimicrobials can be identified in MCs, and the presence of cath is necessary for efficient bacterial killing, which suggests that the presenceof cath is vital to the ability of mammalian MCs to participate in antimicrobial defense.

The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders*

Up-regulation of this human cathelicidin gene in inflammatory skin disorders is demonstrated, whereas in normal skin no induction was found, and a protective role for LL-37 is proposed, when the integrity of the skin barrier is damaged, participating in the first line of defense, and preventing local infection and systemic invasion of microbes.

Innate antimicrobial peptide protects the skin from invasive bacterial infection

It is shown that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS).

The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1

It is demonstrated that LL-37 is a potent antisepsis agent with the ability to inhibit macrophage stimulation by bacterial components such as LPS, lipoteichoic acid, and noncapped lipoarabinomannan and protects mice against lethal endotoxemia.

The Human Cationic Antimicrobial Protein (hCAP-18) Is Expressed in the Epithelium of Human Epididymis, Is Present in Seminal Plasma at High Concentrations, and Is Attached to Spermatozoa

The results suggest a key role for hCAP-18 in the antibacterial integrity of the male reproductive system and the attachment of h CAP-18 to spermatozoa may implicate a role for the protein in conception in conception.

Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide

It is demonstrated that expression of an antimicrobial peptide by gene transfer results in augmentation of the innate immune response, providing support for the hypothesis that vertebrate antimicro peptides protect against microorganisms in vivo.

The role of antimicrobial peptides in animal defenses.

  • R. HancockM. G. Scott
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
It is proposed that cationic antimicrobial peptides, which are induced by LPS and are able to dampen the septic response of animal cells to LPS, have a role in feedback regulation of cytokine responses.

Cell Differentiation Is a Key Determinant of Cathelicidin LL-37/Human Cationic Antimicrobial Protein 18 Expression by Human Colon Epithelium

It is concluded that differentiated human colon epithelium expresses LL-37/hCAP18 as part of its repertoire of innate defense molecules and that the distribution and regulated expression of LL- 37/h CAP18 in the colon differs markedly from that of other enteric antimicrobial peptides, such as defensins.

Protective Effects of a Human 18-Kilodalton Cationic Antimicrobial Protein (CAP18)-Derived Peptide against Murine Endotoxemia

Results indicate that CAP18109–135 is capable of preventing antibiotic-induced endotoxic shock in mice with septicemia and that the effect is due to its LPS-neutralizing activity rather than to its antibacterial activity.