Human casein kinase II. The subunit alpha protein activates transcription of the subunit beta gene.

@article{Robitzki1993HumanCK,
  title={Human casein kinase II. The subunit alpha protein activates transcription of the subunit beta gene.},
  author={A Robitzki and L Bodenbach and H F Voss and Walter G. Pyerin},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 8},
  pages={5694-702}
}
Casein kinase II (CKII), an ubiquitous serine/threonine protein kinase in control of a variety of crucial cellular functions, is composed of catalytic subunits (alpha and alpha') and regulatory subunits (beta). The adjusted activity of CKII is determined by the actual conformational state of CKII beta and the stoichiometry of the CKII subunits. Thus, the expression control of CKII beta is of particular concern. Carrying out gel shifts and footprints with affinity-purified proteins and cellular… CONTINUE READING