Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis.

  title={Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis.},
  author={Gijs F M Verheijden and Antonius W. M. Rijnders and Ebo Bos and Christina J J Coenen-de Roo and Catharina J van Staveren and Andr{\'e} M. M. Miltenburg and Jocelijn Meijerink and Dirk Elewaut and Filip de Keyser and Eric M. Veys and Annemieke M. H. Boots},
  journal={Arthritis and rheumatism},
  volume={40 6},
OBJECTIVE To identify a cartilage-derived autoantigen that is relevant to the rheumatoid arthritis (RA) disease process. METHODS A DR4 (DRB1*0401) peptide binding motif was used for the selection of potential self reactive peptides within human cartilage glycoprotein-39 (HC gp-39), a protein that is differentially expressed at the site of chronic inflammation. Synthetic peptides accommodating the motif were tested for binding the RA-associated DR4 (DRB1*0401) molecules. High-affinity binders… CONTINUE READING

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