Human cardiac stem cell differentiation is regulated by a mircrine mechanism.

@article{Hosoda2011HumanCS,
  title={Human cardiac stem cell differentiation is regulated by a mircrine mechanism.},
  author={Toru Hosoda and Hanqiao Zheng and Mauricio Castro Cabral-da-Silva and Fumihiro Sanada and Noriko Ide-Iwata and Barbara Og{\'o}rek and João Ferreira-Martins and Christian Arranto and Domenico D'Amario and Federica del Monte and Konrad Urbanek and David A D'Alessandro and Robert E. Michler and Piero Anversa and Marcello Rota and Jan Kajstura and Annarosa Leri},
  journal={Circulation},
  year={2011},
  volume={123 12},
  pages={
          1287-96
        }
}
BACKGROUND Cardiac stem cells (CSCs) delivered to the infarcted heart generate a large number of small fetal-neonatal cardiomyocytes that fail to acquire the differentiated phenotype. However, the interaction of CSCs with postmitotic myocytes results in the formation of cells with adult characteristics. METHODS AND RESULTS On the basis of results of in vitro and in vivo assays, we report that the commitment of human CSCs (hCSCs) to the myocyte lineage and the generation of mature working… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 116 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Similar Papers

Loading similar papers…