Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system.

Abstract

BACKGROUND Protein kinases A (PKA) and C (PKC) are activated in ischemic preconditioning and heart failure, conditions in which patients develop arrhythmias. The native inward rectifier potassium current (IK1) plays a central role in the stabilization of the resting membrane potential and the process of arrhythmogenesis. This study investigates the… (More)

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@article{Karle2002HumanCI, title={Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system.}, author={Christoph Karle and Edgar Zitron and Wei Zhang and Gunnar Wendt-Nordahl and Sven Kathoefer and Dierk Thomas and Bernd Gut and Eberhard P. Scholz and Christian-Friedrich Vahl and Hugo A. Katus and Johann Kiehn}, journal={Circulation}, year={2002}, volume={106 12}, pages={1493-9} }