Human carcinoembryonic antigen cDNA expressed in rat carcinoma cells can function as target antigen for tumor localization of antibodies in nude rats and as rejection antigen in syngeneic rats.

Abstract

We have tried to develop a new model consisting of rats transplanted with syngeneic colon carcinoma PROb cells transfected with cDNA coding for the carcinoembryonic antigen (CEA), the human tumor marker most commonly used as target for MAbs. The antigenic density of the 4 CEA-expressing clones selected for a precise characterization ranged from 5 x 10(4) to… (More)

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@article{Pelegrin1992HumanCA, title={Human carcinoembryonic antigen cDNA expressed in rat carcinoma cells can function as target antigen for tumor localization of antibodies in nude rats and as rejection antigen in syngeneic rats.}, author={Andr{\'e} Pelegrin and Alexey V. Terskikh and Daniel Hayoz and Yves Chalandon and Nils Olsson and S{\'e}rgio Folli and Franz Buchegger and Bernd Kromer and K. Schwarz and M. Martin}, journal={International journal of cancer}, year={1992}, volume={52 1}, pages={110-9} }