Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor.

@article{Scobie2003HumanCM,
  title={Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor.},
  author={Heather M Scobie and G. Jonah A. Rainey and Kenneth A. Bradley and John A. T. Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 9},
  pages={5170-4}
}
Bacillus anthracis secretes two bipartite toxins thought to be involved in anthrax pathogenesis and resulting death of the host. The current model for intoxication is that protective antigen (PA) toxin subunits bind a single group of cell-surface anthrax toxin receptors (ATRs), encoded by the tumor endothelial marker 8 (TEM8) gene. The ATR/TEM8-PA interaction is mediated by the receptor's extracellular domain related to von Willebrand factor type A or integrin inserted domains (VWA/I domains… CONTINUE READING
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