Human cancers express mutator phenotypes: origin, consequences and targeting

Abstract

Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for… (More)
DOI: 10.1038/nrc3063

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