Human cancers converge at the HIF-2alpha oncogenic axis.

@article{Franovic2009HumanCC,
  title={Human cancers converge at the HIF-2alpha oncogenic axis.},
  author={Aleksandra Franovic and Chet E Holterman and Josianne Payette and Stephen Q. S. Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 50},
  pages={
          21306-11
        }
}
Cancer development is a multistep process, driven by a series of genetic and environmental alterations, that endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signal autonomy, the first hallmark of malignancies, can be acquired through multiple genetic mutations that activate an array of complex, cancer-specific growth circuits [Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70; Vogelstein B, Kinzler KW (2004) Cancer… CONTINUE READING
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