Human cancer syndromes: clues to the origin and nature of cancer.

@article{Fearon1997HumanCS,
  title={Human cancer syndromes: clues to the origin and nature of cancer.},
  author={Eric R. Fearon},
  journal={Science},
  year={1997},
  volume={278 5340},
  pages={
          1043-50
        }
}
More than 20 different hereditary cancer syndromes have now been defined and attributed to specific germline mutations in various inherited cancer genes. Collectively, the syndromes affect about 1 percent of cancer patients. An individual who carries a mutant allele of an inherited cancer gene has a variable risk of cancer that is influenced by the particular mutation, other cellular genes, and dietary, lifestyle, and environmental factors. Though hereditary cancer syndromes are rare, their… CONTINUE READING

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