Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres.

@article{Xu2007HumanCC,
  title={Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres.},
  author={Lifeng Xu and Elizabeth H Blackburn},
  journal={Molecular cell},
  year={2007},
  volume={28 2},
  pages={315-27}
}
Using a modified single telomere length analysis protocol (STELA) to clone and examine the sequence composition of individual human XpYp telomeres, we discovered a distinct class of extremely short telomeres in human cancer cells with active telomerase. We name them "t-stumps," to distinguish them from the well-regulated longer bulk telomeres. T-stumps contained arrangements of telomeric repeat variants and a minimal run of seven canonical telomeric TTAGGG repeats, but all could bind at least… CONTINUE READING
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