Human cancer cells exhibit protein kinase C-dependent c-erbB-2 transmodulation that correlates with phosphatase sensitivity and kinase activity.

@article{Ouyang1996HumanCC,
  title={Human cancer cells exhibit protein kinase C-dependent c-erbB-2 transmodulation that correlates with phosphatase sensitivity and kinase activity.},
  author={Xuesong Ouyang and Tim Gulliford and Hongquan Zhang and Guo Cai Huang and Richard J. Epstein},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 36},
  pages={21786-92}
}
The c-erbB-2 receptor tyrosine kinase is often overexpressed in human tumors, but the functional implications of this phenotype remain unclear. We previously used phosphorylation-specific antibodies to define major differences in c-erbB-2 tyrosine kinase activity between overexpressing human tumor cell lines (Epstein, R. J., Druker, B. J., Roberts, T. M., and Stiles, C. D. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10435-10439). Here we extend this approach to define the relationship between c… CONTINUE READING

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