Human cancer cell lines: fact and fantasy

  title={Human cancer cell lines: fact and fantasy},
  author={John R. W. Masters},
  journal={Nature Reviews Molecular Cell Biology},
Cancer cell lines are used in many biomedical research laboratories. Why, then, are they often described as unrepresentative of the cells from which they were derived? Here, I argue that they have been unjustly accused. Under the right conditions, and with appropriate controls, properly authenticated cancer cell lines retain the properties of the cancers of origin. 
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