Human cancer cell lines: fact and fantasy

@article{Masters2000HumanCC,
  title={Human cancer cell lines: fact and fantasy},
  author={John R. W. Masters},
  journal={Nature Reviews Molecular Cell Biology},
  year={2000},
  volume={1},
  pages={233-236}
}
Cancer cell lines are used in many biomedical research laboratories. Why, then, are they often described as unrepresentative of the cells from which they were derived? Here, I argue that they have been unjustly accused. Under the right conditions, and with appropriate controls, properly authenticated cancer cell lines retain the properties of the cancers of origin. 
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References

Publications referenced by this paper.
Showing 1-10 of 35 references

p 53 alterations in human leukemia - lymphoma cell lines : in vitro artefact or prerequisite for cell immortalization ?

D. T. Ross
Leukemia • 2000

p53 alterations in human leukemialymphoma cell lines: in vitro artefact or prerequisite for cell immortalization? Leukemia

Drexler, G H.
2000

Comparison of features of human lung cancer cell lines and their corresponding tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research • 1999

Human Cell Culture Volume 1, Cancer Cell Lines Part 1 (eds Masters

Hsu, M.-Y, D. A. Elder, M. Herlyn
1999

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