Human cancer, PTEN and the PI-3 kinase pathway.

  title={Human cancer, PTEN and the PI-3 kinase pathway.},
  author={Ramon E. Parsons},
  journal={Seminars in cell & developmental biology},
  volume={15 2},
The PI-3 kinase pathway is a major driving force for human cancer. One common way of stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor suppressor. The mechanisms of PTEN inactivation include mutation, epigenetic silencing and post-translational modification. Improved insight into the regulation of PTEN is leading to a richer understanding of the contribution of PTEN and the PI-3 kinase pathway to human tumors. Understanding the pathology of PI-3 kinase signaling… CONTINUE READING


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