Human breast carcinoma cells synthesize a protein immunorelated to platelet glycoprotein-Ib alpha with different functional properties.

@article{Oleksowicz1997HumanBC,
  title={Human breast carcinoma cells synthesize a protein immunorelated to platelet glycoprotein-Ib alpha with different functional properties.},
  author={Leslie Oleksowicz and Janice P Dutcher and Margie DeLeon-Fernandez and Elisabeth Paietta and Paul Etkind},
  journal={The Journal of laboratory and clinical medicine},
  year={1997},
  volume={129 3},
  pages={337-46}
}
Although tumor cell-induced platelet aggregation is thought to mediate an early step in the metastatic process, little is known about tumor adhesive receptors responsible for the initial platelet-tumor attachments. Because our preliminary work demonstrated that a platelet-immunorelated glycoprotein Ib alpha (GPIb alpha) receptor expressed by the human breast carcinoma cell line MCF-7 participates in tumor-induced platelet aggregation, we examined the synthesis and functional characteristics of… CONTINUE READING
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