Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

@article{Pvek2005HumanBC,
  title={Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.},
  author={Petr P{\'a}vek and Gracia Merino and E. B. Wagenaar and Ellen Bolscher and Martina Novotn{\'a} and Johan W. Jonker and Alfred H Schinkel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={312 1},
  pages={144-52}
}
The breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette drug efflux transporter that extrudes xenotoxins from cells, mediating drug resistance and affecting the pharmacological behavior of many compounds. To study the interaction of human wild-type BCRP with steroid drugs, hormones, and the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), we expressed human BCRP in the murine MEF3.8 fibroblast cell line, which lacks Mdr1a/1b P-glycoprotein and Mrp1… CONTINUE READING
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