Human brain pericytes as a model system to study the pathogenesis of cerebrovascular amyloidosis in Alzheimer's disease.

@article{Verbeek1999HumanBP,
  title={Human brain pericytes as a model system to study the pathogenesis of cerebrovascular amyloidosis in Alzheimer's disease.},
  author={Marcel M Verbeek and Irene Otte-H{\"o}ller and Dirk J. Ruiter and Robert M. W. de Waal},
  journal={Cellular and molecular biology},
  year={1999},
  volume={45 1},
  pages={37-46}
}
Cerebrovascular amyloidosis belongs to the pathological hallmarks of Alzheimer's disease brains. Although definite proof is still lacking, it is very well possible that the amyloid and its associated proteins are produced locally in the brain. In this paper we describe the development of a model system of cultured human brain pericytes to study the mechanisms of microvascular amyloid formation in vitro. These cultured cells may serve to study several aspects of cerebrovascular amyloidosis… CONTINUE READING

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