Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome.

Abstract

In brain, nucleoside diphosphate kinase (NDPK) and its coding gene, nm23, have been implicated to modulate neuronal cell proliferation, differentiation, and neurite outgrowth. However, a role of NDPK in neurodegenerative diseases has not been reported yet. Using proteomics techniques, we evaluated the protein levels of NDPK-A in seven brain regions from… (More)

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@article{Kim2002HumanBN, title={Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome.}, author={Seong Hwan Kim and Michael S Fountoulakis and Nigel J. Cairns and Gert Lubec}, journal={Biochemical and biophysical research communications}, year={2002}, volume={296 4}, pages={970-5} }