Human brain microvascular endothelial cell traversal by Borrelia burgdorferi requires calcium signaling.

@article{Grab2009HumanBM,
  title={Human brain microvascular endothelial cell traversal by Borrelia burgdorferi requires calcium signaling.},
  author={Dennis J. Grab and Elvis Nyarko and Olga V. Nikolskaia and Yuri Kim and John Stephen Dumler},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2009},
  volume={15 5},
  pages={422-6}
}
Neurological manifestations of Lyme disease (or neuroborreliosis) occur variably and while it is clear that Borrelia burgdorferi can invade the nervous system, how it does so is not well understood. Pathogen penetration through the blood brain barrier (BBB) is often influenced by calcium signaling in the endothelial cells triggered by extracellular host-pathogen interactions. We examined the traversal of B. burgdorferi across the human BBB using in vitro model systems constructed of human brain… CONTINUE READING
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