Human brain evolution: transcripts, metabolites and their regulators

@article{Somel2013HumanBE,
  title={Human brain evolution: transcripts, metabolites and their regulators},
  author={Mehmet Somel and Xiling Liu and Philipp Khaitovich},
  journal={Nature Reviews Neuroscience},
  year={2013},
  volume={14},
  pages={112-127}
}
What evolutionary events led to the emergence of human cognition? Although the genetic differences separating modern humans from both non-human primates (for example, chimpanzees) and archaic hominins (Neanderthals and Denisovans) are known, linking human-specific mutations to the cognitive phenotype remains a challenge. One strategy is to focus on human-specific changes at the level of intermediate phenotypes, such as gene expression and metabolism, in conjunction with evolutionary changes in… CONTINUE READING
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