Human brain acyl-CoA hydrolase isoforms encoded by a single gene.

  title={Human brain acyl-CoA hydrolase isoforms encoded by a single gene.},
  author={Junji Yamada and Yu Kuramochi and Mitsuhiro Takagi and Takafumi Watanabe and Tetsuya Suga},
  journal={Biochemical and biophysical research communications},
  volume={299 1},
Acyl-CoA hydrolases are a group of enzymes that catalyze the hydrolysis of acyl-CoA thioesters to free fatty acids and CoA-SH. The human brain acyl-CoA hydrolase (BACH) gene comprises 13 exons, generating several isoforms through the alternative use of exons. Four first exons (1a-1d) can be used, and three patterns of splicing occur at exon X located between exons 7 and 8 that contains an internal 3(')-splice acceptor site and creates premature stop codons. When examined with green fluorescent… CONTINUE READING
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