Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs

  title={Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs},
  author={Markus Brameier and Astrid Herwig and Richard Reinhardt and Lutz Walter and Jens Gruber},
  journal={Nucleic Acids Research},
  pages={675 - 686}
Small nucleolar RNAs (snoRNAs) and microRNAs are two classes of non-protein-coding RNAs with distinct functions in RNA modification or post-transcriptional gene silencing. In this study, we introduce novel insights to RNA-induced gene activity adjustments in human cells by identifying numerous snoRNA-derived molecules with miRNA-like function, including H/ACA box snoRNAs and C/D box snoRNAs. In particular, we demonstrate that several C/D box snoRNAs give rise to gene regulatory RNAs, named sno… 

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