• Corpus ID: 24672615

Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.

@article{Zhou1995HumanBD,
  title={Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.},
  author={L. J. Zhou and Thomas F. Tedder},
  journal={Journal of immunology},
  year={1995},
  volume={154 8},
  pages={
          3821-35
        }
}
Dendritic cells are potent APC that initiate primary T cell-dependent immune responses. The lack of lineage-associated cell surface Ags for human dendritic cells has made characterization of this lineage difficult. In this study, analysis of leukocyte subpopulations isolated from human blood revealed that circulating or cultured B and T cells, NK cells, and monocytes did not express CD83, whereas CD83+ cells were predominantly found in the dendritic cell-enriched metrizamide low density… 

CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

  • L. ZhouT. Tedder
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
The identification of specific culture conditions that generate large numbers of dendritic cells from purified monocytes uncovers an important step in dendrite cell maturation that will allow the further characterization of their role in autoimmune diseases, graft rejection, and human immunodeficiency virus infection.

Expression of CD86 on Human Marrow CD34+ Cells Identifies Immunocompetent Committed Precursors of Macrophages and Dendritic Cells

It is shown that CD34+/CD86+ cells can also present tetanus toxoid antigen to memory CD4+ T cells and are committed precursors of both macrophages and dendritic cells.

Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells.

It is demonstrated that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells following activation with antigenic peptides or T cell receptor-specific mAb, and is involved in the regulation of T cell responses.

Expression of CD 86 on Human Marrow CD 34 1 Cells Identifies Immunocompetent Committed Precursors of Macrophages and Dendritic Cells

It is shown that CD341/CD861 cells can also present tetanus toxoid antigen to memory CD41 T cells and are committed precursors of both macrophages and dendritic cells.

Human renal‐cell carcinoma tissue contains dendritic cells

The failure of patients with renal‐cell carcinoma to mount an anti‐tumor immune response despite the presence of professional antigen‐presenting cells in the tumor tissue suggests that tumor‐associated dendritic cells are suppressed in situ, in a similar way to that described for tumor‐infiltrating lymphocytes.

Expression of CD86 on human marrow CD34(+) cells identifies immunocompetent committed precursors of macrophages and dendritic cells.

Macrophages and dendritic cells derive from a hematopoietic stem cell and the existence of a common committed progenitor has been hypothesized. We have recently found in normal human marrow a subset

Dendritic Cell Surface Molecules

Dendritic cells (DC) are specialist antigen presenting cells (APC) derived in common with other leukocytes from bone marrow stem cells that after interacting with antigen migrate to the T lymphocyte dependent areas of lymph nodes, where they deliver stimulatory signals to responding T lymphocytes.

Human CD 14 leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and lL-4

It is concluded that human CD14’ leukocytes acquire the phenotype and function of DC when cultured in GM-CSF and IL-4.

CD83 Expression Is a Sensitive Marker of Activation Required for B Cell and CD4+ T Cell Longevity In Vivo1

The restricted expression pattern of CD83, its rapid induction following B cell and T cell activation, and its requirement for B and CD4+ T cell longevity demonstrate that CD83 is a functionally significant and sensitive marker of early lymphocyte activation in vivo.

Phenotypic and Functional Properties of Dendritic Cells Isolated from Human Peripheral Blood in Comparison with Mononuclear Cells and T Cells

Compared with blood MNC and T cells, DCs showed a high level of spontaneous proliferation and nitric oxide production, as well as strong proliferative responses in mixed leucocyte reactions.
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