Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9.

@article{Tversky2008HumanBD,
  title={Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9.},
  author={Jody R Tversky and Thi Kim Van Le and Anja P. Bieneman and Kristin L. Chichester and Robert M. Hamilton and John T. Schroeder},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2008},
  volume={38 5},
  pages={781-8}
}
BACKGROUND High-affinity IgE receptor (Fc epsilon RI) expression on blood dendritic cells reportedly correlates with serum IgE levels. Our studies demonstrate that plasmacytoid dendritic cells (pDCs) secrete pro-inflammatory cytokines (IL-6, TNF-alpha) following Fc epsilon RI stimulation - a mode of activation that simultaneously reduces expression of Toll… CONTINUE READING