Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus.

@article{Yoshio2013HumanBD,
  title={Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus.},
  author={Sachiyo Yoshio and Tatsuya Kanto and Shoko Kuroda and Tokuhiro Matsubara and Koyo Higashitani and Naruyasu Kakita and Hisashi Ishida and Naoki Hiramatsu and Hiroaki Nagano and M Sugiyama and Kazumoto Murata and Takasuke Fukuhara and Yoshiharu Matsuura and Norio Hayashi and Masashi Mizokami and Tetsuo Takehara},
  journal={Hepatology},
  year={2013},
  volume={57 5},
  pages={1705-15}
}
UNLABELLED The polymorphisms in the interleukin (IL)-28B (interferon-lambda [IFN]-λ3) gene are strongly associated with the efficacy of hepatitis C virus (HCV) clearance. Dendritic cells (DCs) sense HCV and produce IFNs, thereby playing some cooperative roles with HCV-infected hepatocytes in the induction of interferon-stimulated genes (ISGs). Blood dendritic cell antigen 3 (BDCA3)(+) DCs were discovered as a producer of IFN-λ upon Toll-like receptor 3 (TLR3) stimulation. We thus aimed to… CONTINUE READING