Human biodistribution and dosimetry of the PET perfusion agent copper-62-PTSM.

  title={Human biodistribution and dosimetry of the PET perfusion agent copper-62-PTSM.},
  author={Thomas R Wallhaus and Jeffrey Lacy and John Whang and Mark A Green and Robert J. Nickles and Caitlin Stone},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={39 11},
UNLABELLED Copper-62-pyruvaldehyde bis(N4-methyl)thiosemicarbazone (PTSM) has been proposed as a generator-produced radiopharmaceutical for perfusion imaging using PET. Several clinical studies have demonstrated the ability of 62Cu-PTSM to quantitate myocardial and cerebral perfusion in humans. Because 62Cu-PTSM is generator-produced, it can be provided to clinical centers without cyclotron availability and, therefore, represents a cost-effective, practical PET perfusion tracer for clinical… CONTINUE READING
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