Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

@article{Ananthanarayanan2001HumanBS,
  title={Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.},
  author={Meenakshisundaram Ananthanarayanan and Nagaraj Balasubramanian and Makoto Makishima and David J Mangelsdorf and Frederick J. Suchy},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 31},
  pages={28857-65}
}
The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion. Recent studies have demonstrated that the expression of this transporter is sensitive to the flux of bile acids through the hepatocyte, possibly at the level of transcription of the BSEP gene. To determine the mechanisms underlying the regulation of BSEP by bile acids, the promoter of the BSEP gene… CONTINUE READING
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