Human beta-secretase and Alzheimer's disease.

  title={Human beta-secretase and Alzheimer's disease.},
  author={Martin Citron},
  journal={Expert opinion on therapeutic targets},
  volume={5 3},
  • Martin Citron
  • Published 2001 in Expert opinion on therapeutic targets
Alzheimer's disease (AD) is a huge unmet medical need. Studies of the brain pathology and genetics of familial forms of AD have led to the amyloid cascade hypothesis, stating that Abeta42, a proteolytic breakdown product of the large amyloid precursor protein, plays an early and critical role in AD pathogenesis. Abeta42 generation requires two proteases… CONTINUE READING