Human beta-myosin heavy chain mRNA prevalence is inversely related to the degree of methylation of regulatory elements.

@article{Clifford1998HumanBH,
  title={Human beta-myosin heavy chain mRNA prevalence is inversely related to the degree of methylation of regulatory elements.},
  author={Christine Clifford and Derek J Nunez},
  journal={Cardiovascular research},
  year={1998},
  volume={38 3},
  pages={736-43}
}
OBJECTIVE Methylation of cytosine in CG dinucleotides within regulatory elements is believed to silence gene expression. These dinucleotides occur in certain important regulatory elements in the promoter region of the human beta-myosin heavy chain (beta-MHC) gene. We therefore investigated whether methylation of these elements correlates with beta-MHC gene transcription in human 'expressing' (right atrial) and 'non-expressing' (peripheral blood leucocytes) cells. METHODS We employed 2… CONTINUE READING

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