Human beta-globulin factors affecting growth of human lymphocytes and mouse fibroblasts.

@article{Thomou1980HumanBF,
  title={Human beta-globulin factors affecting growth of human lymphocytes and mouse fibroblasts.},
  author={H. Thomou and Stauros Koussoulakos and Dimitri Stathakos},
  journal={Journal of cell science},
  year={1980},
  volume={44},
  pages={285-97}
}
Evidence is presented to show the existence in human beta-globulin (Cohn fraction III) of 2 growth-promoting factors that stimulate DNA synthesis and cell division in human lymphocytes and 3T3 B mouse fibroblasts. After extraction of human beta-globulins at pH 3.0 in 0.1 M NaCl followed by sieve chromatography on Sephadex, 2 distinct fractions were obtained containing the biological activity; one of polypeptide nature and molecular weight of approx. 10 000 Daltons and the other consisting of a… CONTINUE READING