Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors.

@article{Varoga2005HumanB3,
  title={Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors.},
  author={Deike J. Varoga and Thomas Pufe and J{\"u}rgen Harder and J. Schr{\"o}der and Rolf Mentlein and Ulf Meyer-Hoffert and Mary B Goldring and Bernhard N. Tillmann and Joachim Hassenpflug and Friedrich Paulsen},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 6},
  pages={1736-45}
}
OBJECTIVE Beta-defensins are broad-spectrum antimicrobial peptides (APs) that are components of innate immunity. Recent investigations showed the induction of beta-defensins in synovial membranes of osteoarthritic (OA) joints and suggested that they have functions other than the ability to kill microbes. As a result of these findings, we undertook this study to investigate the production of human beta-defensin 3 (HBD-3) in OA cartilage and to determine its influence on chondrocyte function… CONTINUE READING

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