Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

@inproceedings{Chen2017HumanBC,
  title={Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis},
  author={Chunguang Chen and Christian Cohrs and Julia Stertmann and Robert Bozsak and Stephan Speier},
  booktitle={Molecular metabolism},
  year={2017}
}
BACKGROUND Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells. Thus, deficiency in either beta cell mass or function, or both, can lead to insufficient levels of insulin, resulting in hyperglycemia and diabetes. Nonetheless, the precise contribution of beta cell mass and function to the pathogenesis of diabetes as well as the underlying… CONTINUE READING
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