Human basophil degranulation triggered by very dilute antiserum against IgE

@article{Davenas1988HumanBD,
  title={Human basophil degranulation triggered by very dilute antiserum against IgE},
  author={E. Davenas and F. Beauvais and J. Amara and M. Oberbaum and B. Robinzon and A. Miadonnai and A. Tedeschi and B. Pomeranz and P. Fortner and P. Belon and J. Sainte-Laudy and B. Poitevin and J. Benveniste},
  journal={Nature},
  year={1988},
  volume={333},
  pages={816-818}
}
When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. The latter can be demonstrated at dilutions of anti-IgE that range from 1 x 10(2) to 1 x 10(120); over that range, there are successive peaks of degranulation from 40 to 60% of the basophils, despite the calculated absence of any anti… Expand
Inhibition of human basophil activation by high dilutions of histamine
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