Human basophil degranulation triggered by very dilute antiserum against IgE

@article{Davenas1988HumanBD,
  title={Human basophil degranulation triggered by very dilute antiserum against IgE},
  author={Elisabeth Davenas and Frederick Beauvais and J Amara and Menachem Oberbaum and Boaz Robinzon and A. Miadonnai and Alberto Tedeschi and Bruce A. Pomeranz and P A Fortner and Ph. Belon and Jean Sainte-Laudy and Bernard Poitevin and Jacques E. Benveniste},
  journal={Nature},
  year={1988},
  volume={333},
  pages={816-818}
}
  • Elisabeth Davenas, Frederick Beauvais, +10 authors Jacques E. Benveniste
  • Published 1988
  • Medicine, Chemistry
  • Nature
  • When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. The latter can be demonstrated at dilutions of anti-IgE that range from 1 x 10(2) to 1 x 10(120); over that range, there are successive peaks of degranulation from 40 to 60% of the basophils, despite the calculated absence of any anti… CONTINUE READING

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