Human basophil degranulation is not triggered by very dilute antiserum against human IgE

@article{Hirst1993HumanBD,
  title={Human basophil degranulation is not triggered by very dilute antiserum against human IgE},
  author={Stephen J. Hirst and N. A. Hayes and Jane Burridge and Frederick Leon Pearce and John C. Foreman},
  journal={Nature},
  year={1993},
  volume={366},
  pages={525-527}
}
We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (102–10120) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following as closely as possible the methods of the original study, we can find no evidence for any periodic or polynomial change of degranulation as a function of anti-lgE dilution. Our results… 

Basophil models of homeopathy: a sceptical view.

  • M. Ennis
  • Biology
    Homeopathy : the journal of the Faculty of Homeopathy
  • 2010

Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study

TLDR
It is shown that low and high dilutions of histamine inhibit CD203c up-regulation in anti-IgE stimulated basophils, using a strictly standardized flow cytometry protocol and a new dilution/succussion procedure.

Histamine dilutions modulate basophil activation

TLDR
In 3 different types of experiment, it has been shown that high dilutions of histamine may indeed exert an effect on basophil activity, with the greatest inhibitory effects seen at lower levels of stimulation.

Original Research Papers Histamine dilutions modulate basophil activation

TLDR
High dilutions of histamine may indeed exert an effect on basophil activity and this activity observed by staining basophils with alcian blue was confirmed by flow cytometry.

Sensitive Flow Cytometric Method to Test Basophil Activation Influenced by Homeopathic Histamine Dilutions

TLDR
A 3-color flow cytometric method with enhanced accuracy was established to measure the effects from homeopathic solutions in an in-vitro cell system and documented an unequivocally inhibited basophil activation by anti-IgE.

Survey of immuno-allergological ultra high dilution research.

  • B. Poitevin
  • Biology, Medicine
    Homeopathy : the journal of the Faculty of Homeopathy
  • 2015

Immunology and Homeopathy. 2. Cells of the Immune System and Inflammation

TLDR
This review of literature unknown to most people will give an original and useful insight into the ‘state-of-the-art’ of homeopathy, without final conclusions ‘for’ or ‘against’ this modality.
...

References

Human basophil degranulation triggered by very dilute antiserum against IgE

TLDR
When human polymorphonuclear basophils are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties, and transmission of the biological information could be related to the molecular organization of water.