Human basophil degranulation is not triggered by very dilute antiserum against human IgE

@article{Hirst1993HumanBD,
  title={Human basophil degranulation is not triggered by very dilute antiserum against human IgE},
  author={Stephen J. Hirst and N. A. Hayes and Jane Burridge and Frederick Leon Pearce and John C. Foreman},
  journal={Nature},
  year={1993},
  volume={366},
  pages={525-527}
}
We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (102–10120) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following as closely as possible the methods of the original study, we can find no evidence for any periodic or polynomial change of degranulation as a function of anti-lgE dilution. Our results… 

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References

Human basophil degranulation triggered by very dilute antiserum against IgE

When human polymorphonuclear basophils are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties, and transmission of the biological information could be related to the molecular organization of water.