Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

@article{Florkiewicz1989HumanBF,
  title={Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.},
  author={Robert Zigmond. Florkiewicz and Andreas Sommer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 11},
  pages={
          3978-81
        }
}
Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator ATG codon. However, a bFGF protein isolated from human placenta contains two additional amino acids NH2-terminal to the predicted initiator methionine. We report here that the human cell line SK-HEP… CONTINUE READING
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