Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms.

Abstract

This article reviews the current knowledge on alpha-synuclein and its cellular locations in studies using human brain tissue. Alterations in the conformation and distribution of alpha-synuclein are examined in Parkinson's disease and the relationship between clinical symptoms and pathology explored. alpha-Synuclein as a molecular chaperone has several… (More)

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