Human base excision repair creates a bias toward -1 frameshift mutations.

Abstract

Frameshift mutations are particularly deleterious to protein function and play a prominent role in carcinogenesis. Most commonly these mutations involve the insertion or omission of a single nucleotide by a DNA polymerase that slips on a damaged or undamaged template. The mismatch DNA repair pathway can repair these nascent polymerase errors. However… (More)
DOI: 10.1074/jbc.M110.118596

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