Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway.

@article{Bonaparte2008HumanAC,
  title={Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway.},
  author={Rheba S Bonaparte and Pamela S. Hair and Deepa Banthia and Dawn Marie Marshall and Kenji M Cunnion and Neel K. Krishna},
  journal={Journal of virology},
  year={2008},
  volume={82 2},
  pages={
          817-27
        }
}
Human astroviruses (HAstVs) belong to a family of nonenveloped, icosahedral RNA viruses that cause noninflammatory gastroenteritis, predominantly in infants. Eight HAstV serotypes have been identified, with a worldwide distribution. While the HAstVs represent a significant public health concern, very little is known about the pathogenesis of and host immune response to these viruses. Here we demonstrate that HAstV type 1 (HAstV-1) virions, specifically the viral coat protein (CP), suppress the… CONTINUE READING

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The Astrovirus Capsid: A Review

VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Proteolytic processing of the astrovirus capsid.

  • Journal of virology
  • 2000
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
VIEW 1 EXCERPT

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