Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation.

@article{Hair2009HumanAC,
  title={Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation.},
  author={Pamela S. Hair and Jenny Q. Gronemus and Katrina B. Crawford and Veena Prakash Salvi and Kenji M Cunnion and Nicole M Thielens and G{\'e}rard J. Arlaud and Narinder Rawal and Neel K Krishna},
  journal={Molecular immunology},
  year={2009},
  volume={47 4},
  pages={
          792-8
        }
}
Human astroviruses (HAstVs) constitute a family of non-enveloped, RNA viruses which cause infantile gastroenteritis. We have previously demonstrated that purified HAstV coat protein (CP), multiple copies of which compose the viral capsid, bind C1q resulting in inhibition of classical complement pathway activity. The objective of this study was to further analyze the mechanism by which CP inhibits C1 activation. CP inhibited C1 activation, preventing cleavage of C1s to its active form in the… CONTINUE READING
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