Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis.


BACKGROUND N-acetyltransferase 2 (NAT2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis. OBJECTIVE The present study was designed to evaluate whether acetylation polymorphism plays a role in the susceptibility to p-Phenylenediamine (PPD) sensitization. METHODS The frequencies of seven NAT2 point mutations, namely G191A… (More)