Human artificial chromosomes for gene delivery and the development of animal models.

@article{Kazuki2011HumanAC,
  title={Human artificial chromosomes for gene delivery and the development of animal models.},
  author={Yasuhiro Kazuki and Mitsuo Oshimura},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011},
  volume={19 9},
  pages={1591-601}
}
Random integration of conventional gene delivery vectors such as viruses, plasmids, P1 phage-derived artificial chromosomes, bacterial artificial chromosomes and yeast artificial chromosomes can be associated with transgene silencing. Furthermore, integrated viral sequences can activate oncogenes adjacent to the insertion site resulting in cancer. Various human artificial chromosomes (HACs) exhibit several potential characteristics desired for an ideal gene delivery vector, including stable… CONTINUE READING

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