Human articular chondrocytes immortalized by HPV-16 E6 and E7 genes: Maintenance of differentiated phenotype under defined culture conditions.

@article{Grigolo2002HumanAC,
  title={Human articular chondrocytes immortalized by HPV-16 E6 and E7 genes: Maintenance of differentiated phenotype under defined culture conditions.},
  author={Brunella Grigolo and Livia Roseti and Simona Neri and Pietro Gobbi and Peter Gade Jensen and Eugene O. Major and Andrea Facchini},
  journal={Osteoarthritis and cartilage},
  year={2002},
  volume={10 11},
  pages={879-89}
}
OBJECTIVE To establish an immortalized normal human articular chondrocyte line which could be useful for a better understanding of cell molecular mechanisms relevant for the development of new therapeutic approaches in rheumatic diseases. DESIGN Chondrocytes from human adult articular healthy cartilage were transfected in primary culture with a plasmid containing two human papilloma virus type 16 (HPV-16) early function genes: E6 and E7, using the highly efficient cationic liposome-mediated… CONTINUE READING

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