Human archival tissues provide a valuable source for the analysis of spatial genome organization

  title={Human archival tissues provide a valuable source for the analysis of spatial genome organization},
  author={Thorsten Wiech and Sylvia Timme and Florian N Riede and S. K. Stein and Michael Schuricke and Christoph Cremer and Martin Werner and Michael Hausmann and Axel Walch},
  journal={Histochemistry and Cell Biology},
Sections from archival formalin-fixed, paraffin wax-embedded human tissues are a valuable source for the study of the nuclear architecture of specific tissue types in terms of the three-dimensional spatial positioning and architecture of chromosome territories and sub-chromosomal domains. Chromosome painting, centromeric, and locus-specific probes were hybridized to tissue microarrays prepared from formalin-fixed paraffin wax-embedded samples of pancreas and breast. The cell nuclei were… CONTINUE READING


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