Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

@article{Xu1996HumanAE,
  title={Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.},
  author={P T Xu and Donald E. Schmechel and T R Rothrock-Christian and D S Burkhart and H L Qiu and Brian Popko and Patrick Sullivan and Nobuyo Maeda and Ann M Saunders and A. D. Roses and John R. Gilbert},
  journal={Neurobiology of disease},
  year={1996},
  volume={3 3},
  pages={229-45}
}
Apolipoprotein E (apoE) and its three major alleles (APOE2, E3, and E4) have been implicated in Alzheimer's disease and other neurological disorders. Little is known of the role apoE plays in normal brain function and pathology. To create a model to study apoE in brain, we have generated APOE transgenic mice using microinjection of allele-specific human genomic fragments to establish founders which were then bred to APOE knockout mice lacking a functional mouse apoE protein. This allows the… CONTINUE READING

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